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| core-shell structure; NaHoF4; emission intensity; upconversion; anticancer theranostics |
| Received:September 04, 2020 Revised:September 08, 2020 |
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| DOI：doi：10.3969/j.issn.1007-7545.2020.12.012 |
| KeyWord:core-shell structure; NaHoF4; emission intensity; upconversion; anticancer theranostics |
| Author | Institution |
| WANG Chen |
广西医科大学 肿瘤医学院 |
| LIU Haizhou |
广西医科大学 肿瘤医学院 |
| NING Shufang |
广西医科大学 肿瘤医学院 |
| TANG Yanping |
广西医科大学 肿瘤医学院 |
| ZHANG Litu |
广西医科大学 肿瘤医学院 |
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| Abstract: |
| In order to enhance fluorescence emission ability of NaHoF4 without Ce doping, multilayer core-shell nanoparticles with Yb3+ concentration gradient were designed and prepared, whose microstructures, fluorescence emission abilities, phase structures and anticancer theranostics effects were measured. The results show that prepared hexagonal NaHoF4 particles have good crystallinity with particle size of about 20 nm. The multilayer coating shell is thin and uniform, fluorescence emission intensity of this structure is higher than that of no or single coating shell. Under 980 nm laser irradiation, multilayer NaHoF4 nanoparticles with Ce6 surface modification have good anticancer theranostics effect in HeLa cancer cells. |
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